Dihydroartemisinin 20 mg + Piperaquine Phosphate 160 mg Dispersible Tablets

D-ARTEPP 20/160 mg contains dihydroartemisinin 20 mg (artemisinin derivative) and piperaquine phosphate 160 mg (long-acting bisquinoline antimalarial). Dihydroartemisinin produces free radicals within Plasmodium-infected erythrocytes, leading to rapid parasite clearance, while piperaquine inhibits heme detoxification, causing toxic heme accumulation and sustained antimalarial activity. It is indicated for the treatment of acute uncomplicated and complicated malaria due to Plasmodium falciparum and other susceptible species. It is contraindicated in patients with hypersensitivity to components, severe malaria, and those with known QT prolongation or on QT-prolonging medications.

This combination provides rapid parasite reduction with prolonged post-treatment prophylactic effect, reducing recrudescence. Use with caution in patients with cardiac disorders, electrolyte imbalance, hepatic or renal impairment, and during pregnancy (particularly first trimester unless clinically justified). Common adverse effects include headache, dizziness, gastrointestinal disturbances, and potential QT interval prolongation, requiring caution in at-risk populations.